87503-68-2Relevant articles and documents
Total Synthesis of (+)-Milbemycin β3
Baker, Raymond,O'Mahony, Mary J.,Swain, Christopher J.
, p. 1623 - 1634 (2007/10/02)
The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio
A Directed Aldol Approach to (+)-Milbemycin β3
Kocienski, Philip J.,Street, Stephen D. A.,Yeates, Clive,Campbell, Simon F.
, p. 2171 - 2182 (2007/10/02)
Key steps in a total synthesis of (+)-milbemycin β3 are the construction of the 1,7-dioxaspiroundecane (10) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions for the constr