Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Base Information

• Chemical Name: Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester
• CAS No.: 110522-59-3
• Molecular Formula: C₅₆H₅₅N₇O₁₁P₂S₃
• Molecular Weight: 1160.24
• Mol file: 110522-59-3.mol

Synonyms:

Chemical Property of Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

There total 1 articles about Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(4-Methoxy-phenyl)-thiophosphoramidic acid S-phenyl ester; compound with cyclohexylamine (110522-61-7) + Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester (98889-41-9) → Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester (110522-59-3)

Guidance literature:

With pyridine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride;

DOI:10.1246/cl.1987.117

Reference yield:

Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester (110522-59-3) + triethylamine (121-44-8) → Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-5-[(4-methoxy-phenylamino)-phenylsulfanyl-phosphoryloxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine

Guidance literature:

With pyridine; H₂O₂P*C₅H₅N; at 40 ℃; for 1h;

DOI:10.1246/cl.1987.117

upstream raw materials:

(4-Methoxy-phenyl)-thiophosphoramidic acid S-phenyl ester; compound with cyclohexylamine

Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester