N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

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Chemical Name:N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide
CAS No.:1190390-46-5
Molecular Formula:C₃₄H₃₀F₃N₃O₃S₂
Molecular Weight:649.758
Hs Code.:

Synonyms:N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

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Chemical Property of N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

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Technology Process of N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

There total 13 articles about N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1190393-26-0
tert-butyl(2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl-5-(4-{[(4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}phenyl)sulfonyl]amino}benzyl)pyrrolidine]-1-carboxylate

: 1190390-46-5
N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 1314024-14-0
C₄₅H₅₂F₃N₃O₅S₂Si

: 1190390-46-5
N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

: 1190390-47-6
N-[4-({(2R,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.12.087

Reference yield:

: 1190391-63-9
(R)-2-((S)-phenyl((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

: 1190390-46-5
N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 20 °C / Inert atmosphere

1.2: 16 h / 105 °C

2.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide / N,N-dimethyl-formamide / 5.25 h / 20 °C / Inert atmosphere

3.1: pyrrolidine / N,N-dimethyl-formamide / 3 h / 80 °C

3.2: 3 h / 20 °C

4.1: triethylamine / dichloromethane / 1.5 h / 20 °C

4.2: 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

7.1: pyridine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

8.1: hydrogenchloride / methanol / 0.5 h / 20 °C

With pyrrolidine; pyridine; hydrogenchloride; diphenyl phosphoryl azide; hydrogen; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;