5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide

Base Information

• Chemical Name: 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide
• CAS No.: 1247826-91-0
• Molecular Formula: C₁₇H₁₇Cl₂N₃O₃S₂
• Molecular Weight: 446.378

Synonyms:5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide

Chemical Property of 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide

There total 4 articles about 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Amino-1-methylpiperidine (41838-46-4) + methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylic acid (1247828-46-1) → 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide (1247826-91-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ml200276j

Reference yield:

2,6-dichlorothiophenol (24966-39-0) → 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide (1247826-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 20 °C

2: sulfuric acid / water / 5 h / 100 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 6 h / 20 °C

With sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; water; toluene;

DOI:10.1021/ml200276j

Reference yield:

5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester (57800-76-7) → 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide (1247826-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 20 °C

2: sulfuric acid / water / 5 h / 100 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 6 h / 20 °C

With sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; water; toluene;

DOI:10.1021/ml200276j

upstream raw materials:

4-Amino-1-methylpiperidine

methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylic acid

2,6-dichlorothiophenol

5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester

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