ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

Base Information

Chemical Name:ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate
CAS No.:1202013-60-2
Molecular Formula:C₃₀H₃₅BrN₂O₇
Molecular Weight:615.521
Hs Code.:

Synonyms:ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

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Chemical Property of ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

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Technology Process of ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

There total 11 articles about ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202013-59-9
2-(benzyloxy)-2,2-dimethyl-4-(methylamino)butan-1-ol

: 1202013-55-5
5-(benzyloxy)-3-bromo-4-(ethoxycarbonyl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid

: 1202013-60-2
ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 100-39-0
benzyl bromide

: 1202013-60-2
ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water / 0.67 h / Ultrasonic bath

1.2: 24 h / Reflux

2.1: selenium(IV) oxide / 1,4-dioxane / 6 h / 100 °C

3.1: N-Bromosuccinimide / dichloromethane / 12 h / 20 °C

4.1: Oxone / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 12 h / 20 °C

With 4-methyl-morpholine; selenium(IV) oxide; Oxone; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 79-50-5
pantolactone

: 1202013-60-2
ethyl 3-(benzyloxy)-6-{[2-(benzyloxy)-4-hydroxy-3,3-dimethylbutyl](methyl)aminocarbonyl}-5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: methanol; water / 12 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 36.17 h / Cooling with ice; Reflux

3.2: Cooling with ice

4.1: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 12 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;