Technology Process of Boc-(R)-N(Me)-Leu-Thr[H-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH
There total 21 articles about Boc-(R)-N(Me)-Leu-Thr[H-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
for 4h;
under 760 Torr;
Ambient temperature;
DOI:10.1021/jo961932h
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / DMAP, DCC / CH2Cl2 / 7 h / 0 °C
2: TFA / CH2Cl2 / 0.33 h
3: 76 percent / 1-hydroxybenzotriazole, N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide, N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature
4: 78 percent / H2 / Pd/C / tetrahydrofuran / 1 h / 760 Torr / Ambient temperature
5: 60 percent / DMAP*CF3COOH, N,N'-diisopropylcarbodiimide / CHCl3 / 1.) reflux, 8 h, 2.) room temperature, 16 h
6: 81 percent / aq. NH4OAc, Zn / tetrahydrofuran / 24 h
7: 95 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 760 Torr / Ambient temperature
With
dmap; N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide; ammonium acetate; hydrogen; benzotriazol-1-ol; 4-N,N-dimethylaminopyridine trifluoroacetate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; diisopropyl-carbodiimide; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jo961932h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / 1-hydroxybenzotriazole, N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide, N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature
2: 78 percent / H2 / Pd/C / tetrahydrofuran / 1 h / 760 Torr / Ambient temperature
3: 60 percent / DMAP*CF3COOH, N,N'-diisopropylcarbodiimide / CHCl3 / 1.) reflux, 8 h, 2.) room temperature, 16 h
4: 81 percent / aq. NH4OAc, Zn / tetrahydrofuran / 24 h
5: 95 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 760 Torr / Ambient temperature
With
N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide; ammonium acetate; hydrogen; benzotriazol-1-ol; 4-N,N-dimethylaminopyridine trifluoroacetate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; chloroform; acetonitrile;
DOI:10.1021/jo961932h