5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate
• CAS No.: 183320-37-8
• Molecular Formula: C₄₃H₄₃BrN₅O₁₀P
• Molecular Weight: 900.72

Synonyms:5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate

Chemical Property of 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate

There total 11 articles about 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N6-benzoyl-8-bromoadenosine (183320-32-3) → 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N6-benzoyl-8-bromoadenosine 3'-H-phosphonate (183320-37-8)

Guidance literature:

With 4-methyl-morpholine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; In 1,4-dioxane;

Reference yield:

8-bromoadenosine (2946-39-6) → 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N6-benzoyl-8-bromoadenosine 3'-H-phosphonate (183320-37-8)

Guidance literature:

Multi-step reaction with 7 steps

3: H⁺

4: (C₂H₅)4NBr, KF

7: H₂O

With potassium fluoride; tetraethylammonium bromide; water; hydrogen cation;

Reference yield:

8-bromo-9-(3,5-O-tetraisopropyldisiloxane-1,3-diyl-β-D-ribofuranosyl)adenine (165190-34-1) → 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N6-benzoyl-8-bromoadenosine 3'-H-phosphonate (183320-37-8)

Guidance literature:

Multi-step reaction with 6 steps

2: H⁺

3: (C₂H₅)4NBr, KF

6: H₂O

With potassium fluoride; tetraethylammonium bromide; water; hydrogen cation;

upstream raw materials:

5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine

4,4'-dimethoxytrityl chloride

8-bromoadenosine

8-bromo-9-(3,5-O-tetraisopropyldisiloxane-1,3-diyl-β-D-ribofuranosyl)adenine

Downstream raw materials:

5'-O-dimethoxytrityl-2'-O-(tetrahydropyran-2-yl)-N⁶-benzoyl-8-aminoadenosine 3'-H-phosphonate

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