3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

Base Information

Chemical Name:3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester
CAS No.:226943-07-3
Molecular Formula:C₂₅H₂₆N₂O₈S
Molecular Weight:514.556
Hs Code.:

3-(1-benzenesulfonyl-1<i>H</i>-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

Synonyms:3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

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Chemical Property of 3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

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Technology Process of 3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

There total 5 articles about 3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 82980-12-9
3-ethenyl-1-phenylsulfonyl-1H-indole

: N-(methoxymethyl-N-ethoxycarbonyl)aminomethyl malonate

: 226943-07-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

Guidance literature:: With TEA; titanium tetrachloride; In dichloromethane; for 1.5h; Heating;
DOI:10.1055/s-1999-2708

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 226943-07-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / K₂CO₃ / butan-2-one / 2 h / Heating

2.1: n-BuLi / 1,2-dimethoxy-ethane; hexane / 2 h / 20 °C

2.2: 83 percent / 1,2-dimethoxy-ethane; hexane / 20 °C

3.1: 70 percent / TiCl₄; Et₃N / CH₂Cl₂ / 1 h / Heating

With n-butyllithium; titanium tetrachloride; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; hexane; dichloromethane; butanone; 1.1: Substitution / 2.1: Metallation / 2.2: Condensation / 3.1: Cycloaddition;
DOI:10.1016/S0040-4020(99)00561-X

Reference yield:

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 226943-07-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-pyrrolidine-1,2,2-tricarboxylic acid 1-ethyl ester 2,2-dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / 1,2-dimethoxy-ethane; hexane / 2 h / 20 °C

1.2: 83 percent / 1,2-dimethoxy-ethane; hexane / 20 °C

2.1: 70 percent / TiCl₄; Et₃N / CH₂Cl₂ / 1 h / Heating

With n-butyllithium; titanium tetrachloride; triethylamine; In 1,2-dimethoxyethane; hexane; dichloromethane; 1.1: Metallation / 1.2: Condensation / 2.1: Cycloaddition;
DOI:10.1016/S0040-4020(99)00561-X