1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE

Base Information

• Chemical Name: 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
• CAS No.: 80360-20-9
• Molecular Formula: C15H11 N O3 S
• Molecular Weight: 285.323
• Hs Code.: 2933990090
• Mol file: 80360-20-9.mol

Synonyms:1-(Benzenesulfonyl)-1H-indole-3-carboxaldehyde; 1-(Phenylsulfonyl)-3-formylindole;1-Phenylsulfonyl-1H-indole-3-carboxaldehyde; N-(Phenylsulfonyl)-3-indolecarboxaldehyde;NSC 628191

Chemical Property of 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 1.16E-10mmHg at 25°C
• Melting Point: 157-161oC(lit.)
• Boiling Point: 513.6oC at 760 mmHg
• Flash Point: 264.4oC
• PSA: 64.52000
• Density: 1.31g/cm3
• LogP: 3.77160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE

There total 15 articles about 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + benzenesulfonyl chloride (98-09-9) → 1-(phenylsulfonyl)indole-3-carbaldehyde (80360-20-9)

Guidance literature:

With potassium carbonate; In various solvent(s); for 2h; Heating;

DOI:10.1055/s-1999-2708

Reference yield: 75.0%

N-(phenylsulphonyl)-3-methylindole (58550-84-8) → 1-(phenylsulfonyl)indole-3-carbaldehyde (80360-20-9)

Guidance literature:

With carbon tetrabromide; oxygen; In acetonitrile; at 20 ℃; for 4h; Irradiation; Green chemistry;

DOI:10.1039/c5ra26623h

Reference yield: 35.0%

cyclohexenone (930-68-7) + Se-phenyl 1-(phenylsulfonyl)-3-indolecarboselenoate (459869-42-2) → 1-(phenylsulfonyl)indole-3-carbaldehyde (80360-20-9) + 3-[1-(phenylsulfonyl)-3-indolylcarbonyl]cyclohexanone

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In benzene; Heating;

DOI:10.1021/jo025842q

upstream raw materials:

Indole-3-carboxaldehyde

benzenesulfonyl chloride

3-lithio-1-(phenylsulfonyl)indole

N,N-dimethyl-formamide

Downstream raw materials:

diphenyl(2-hydroxy-2--1-morpholinoethyl)phosphine oxide

[1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(Z)-ylidene]-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-amine

3-(1,3-Dithian-2-yl)-1-(phenylsulfonyl)indole

(1S,3S,3aS,6aR)-3-(1-Benzenesulfonyl-1H-indol-3-yl)-2-(2-bromo-allyl)-5-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester