ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate
CAS No.:1637593-17-9
Molecular Formula:C₁₆H₁₇ClN₂O₇
Molecular Weight:384.773
Hs Code.:

Synonyms:ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

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Chemical Property of ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

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Technology Process of ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

There total 6 articles about ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1637593-16-8
4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoyl chloride

: 105-56-6
ethyl 2-cyanoacetate

: 1637593-17-9
ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

Guidance literature:: ethyl 2-cyanoacetate; With sodium ethanolate; In ethanol; at 40 - 50 ℃; for 0.5h; Reflux;

4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoyl chloride; In tetrahydrofuran; ethanol; at 0 ℃; for 2h;
DOI:10.1080/00304948.2015.1025014

Reference yield:

: 111627-40-8
methyl 4-(3-chloropropoxy)-3-methoxybenzoate

: 1637593-17-9
ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol; water / 12 h / 50 - 60 °C / Green chemistry

1.2: 1 h / 20 °C / pH 2 - 3 / Green chemistry

2.1: nitric acid; acetic acid / 6 h / 40 - 50 °C / Green chemistry

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 20 °C / Green chemistry

4.1: sodium ethanolate / ethanol / 0.5 h / Reflux; Green chemistry

4.2: 2 h / 0 °C / Green chemistry

With oxalyl dichloride; nitric acid; sodium ethanolate; acetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-13023

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1637593-17-9
ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C / Green chemistry

2.1: sodium hydroxide / methanol; water / 12 h / 50 - 60 °C / Green chemistry

2.2: 1 h / 20 °C / pH 2 - 3 / Green chemistry

3.1: nitric acid; acetic acid / 6 h / 40 - 50 °C / Green chemistry

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 20 °C / Green chemistry

5.1: sodium ethanolate / ethanol / 0.5 h / Reflux; Green chemistry

5.2: 2 h / 0 °C / Green chemistry

With oxalyl dichloride; nitric acid; sodium ethanolate; potassium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-13023