N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

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Chemical Name:N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide
CAS No.:1198785-84-0
Molecular Formula:C₁₈H₂₃F₃N₂O₃S
Molecular Weight:404.453
Hs Code.:

Synonyms:N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

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Chemical Property of N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

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Technology Process of N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

There total 11 articles about N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1198785-49-7
N-[1-dimethylaminomethylidene]-2-(4,4,4-trifluoro-1,1-dimethyl-3-oxobutyl)benzenesulfonamide

: 106-96-7
propargyl bromide

: 1198785-84-0
N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

Guidance literature:: propargyl bromide; With aluminium; mercury dichloride; In tetrahydrofuran; at 50 ℃; for 1h;

N-[1-dimethylaminomethylidene]-2-(4,4,4-trifluoro-1,1-dimethyl-3-oxobutyl)benzenesulfonamide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1021/ml500387y

Reference yield:

: 583-53-9
2,3-dibromobenzene

: 1198785-84-0
N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

1.3: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

4.2: 0.92 h / -78 - -20 °C

4.3: 0.5 h / 20 °C

5.1: ammonia / methanol / 18 h / 20 °C

6.1: dichloromethane / 0.5 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

9.1: aluminium; mercury dichloride / tetrahydrofuran / 1 h / 50 °C

9.2: 2 h / -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; ammonia; isopropylmagnesium bromide; Dess-Martin periodane; aluminium; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml500387y

Reference yield:

: 1198785-63-5
4-(2-bromophenyl)-1,1,1-trifluoro-4-methylpentan-2-one

: 1198785-84-0
N-[1-dimethylaminomethylidene]-2-(3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 24 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

3.2: 0.92 h / -78 - -20 °C

3.3: 0.5 h / 20 °C

4.1: ammonia / methanol / 18 h / 20 °C

5.1: dichloromethane / 0.5 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

8.1: aluminium; mercury dichloride / tetrahydrofuran / 1 h / 50 °C

8.2: 2 h / -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; ammonia; Dess-Martin periodane; aluminium; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml500387y