[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Base Information

Chemical Name:[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane
CAS No.:1198785-45-3
Molecular Formula:C₁₈H₂₈BrF₃OSi
Molecular Weight:425.404
Hs Code.:

Synonyms:[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Suppliers and Price of [3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Chemical Property:

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Technology Process of [3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

There total 4 articles about [3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1198785-44-2
4-(2-bromophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1198785-45-3
[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Guidance literature:: 4-(2-bromophenyl)-1,1,1-trifluoro-4-methylpentan-2-ol; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 1198785-63-5
4-(2-bromophenyl)-1,1,1-trifluoro-4-methylpentan-2-one

: 1198785-45-3
[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 24 h / 0 - 20 °C

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ml500387y

Reference yield:

: 583-53-9
2,3-dibromobenzene

: 1198785-45-3
[3-(2-bromophenyl)-3-methyl-1-trifluoromethylbutoxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

1.3: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

3.2: 24 h / 0 - 20 °C

With sodium tetrahydroborate; isopropylmagnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ml500387y