Liothyronine sodium

Base Information

• Chemical Name: Liothyronine sodium
• CAS No.: 55-06-1
• Molecular Formula: C15H11I3NNaO4
• Molecular Weight: 672.96
• Hs Code.: 29379000
• Mol file: 55-06-1.mol

Synonyms:Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI);L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (9CI);3,3',5-Triiodo-L-thyronine sodium salt;3,3',5-Triiodothyronine sodium salt;3,5,3'-Triiodo-L-thyronine monosodium salt;Basoprocin;Cynomel;Cyomel;Cytobin;Cytomel;Cytomel sodium;Cytomine;Ibiothyron;L-Triiodothyroninesodium salt;Liothyroniinde sodium salt;Liothyroninesodium;Sodium 3,3',5-triiodo-L-thyronine;Sodium 3,5,3'-triiodothyronine;Sodium L-3,3',5-triiodothyronine;Sodium L-triiodothyronine;Sodium T3;Sodiumliothyronine;Sodium triiodo-L-thyronine;Sodium triiodothyronine;T3 Sodiumsalt;Tertroxin;Triiodothyronine sodium salt;Triostat;Triothyrone;

Chemical Property of Liothyronine sodium

Chemical Property:

• Appearance/Colour: white to beige powder
• Melting Point: 205 °C (dec.)(lit.)
• Boiling Point: 563.5 °C at 760 mmHg
• Flash Point: 294.6 °C
• PSA: 95.61000
• LogP: 3.31830
• Storage Temp.: 2-8°C
• Sensitive.: Light Sensitive
• Solubility.: 4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
• Water Solubility.: Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most

Purity/Quality:

98% ^*data from raw suppliers

3,3',5'-Triiodo-L-thyronine sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 22-24/25-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: L-3,3',5-Triiodothyronine, Sodium Salt is shown to stimulate respiratory activity at the mitochondrial level. T3 is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine. cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)
• Indications: Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3 alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

Technology Process of Liothyronine sodium

There total 1 articles about Liothyronine sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diiodo-L-thyronine (1041-01-6,534-51-0,5563-89-3,299-82-1) → liothyronine sodium (55-06-1)

Guidance literature:

With iodine; ethylamine; sodium iodide; In water; at 0 - 22 ℃; for 7h; Large scale;

Reference yield: 91.0%

bismuth (III) nitrate pentahydrate + liothyronine sodium (55-06-1) → bismuth triiodothyronine

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield: 61.0%

liothyronine sodium (55-06-1) → (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)-2-iodophenol (1417654-45-5)

Guidance literature:

With lithium borohydride; chloro-trimethyl-silane; In tetrahydrofuran; 1,4-dioxane; at 0 ℃; Inert atmosphere;

upstream raw materials:

3,5-diiodo-L-thyronine

Downstream raw materials:

(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)-2-iodophenol

triiodothyronine

Refernces