1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

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Chemical Name:1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide
CAS No.:1194055-38-3
Molecular Formula:C₂₃H₂₇ClN₄O₄S
Molecular Weight:491.011
Hs Code.:

Synonyms:1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

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Chemical Property of 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

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Technology Process of 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

There total 8 articles about 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1194055-36-1
3-[5-(1-{[1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-butyl)-pyridine-3-sulfonyl]-propionic acid methyl ester

: 1194055-38-3
1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 70 ℃; for 1h;

Reference yield:

: 288252-38-0
1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

: 1194055-38-3
1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 15 h

2: copper(l) iodide / dimethyl sulfoxide / 1.5 h / 130 °C

3: lithium borohydride / tetrahydrofuran / 1 h / 70 °C

With copper(l) iodide; lithium borohydride; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 113118-81-3
5-bromopyridine-3-carbaldehyde

: 1194055-38-3
1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) isopropylate / dichloromethane / 4 h / 60 °C

2.1: tetrahydrofuran; diethyl ether / -78 - 20 °C

3.1: hydrogenchloride; water / 5 h / 20 °C

3.2: pH 8

4.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 15 h

5.1: copper(l) iodide / dimethyl sulfoxide / 1.5 h / 130 °C

6.1: lithium borohydride / tetrahydrofuran / 1 h / 70 °C

With titanium(IV) isopropylate; hydrogenchloride; copper(l) iodide; lithium borohydride; water; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;