((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

Base Information

Chemical Name:((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane
CAS No.:204202-32-4
Molecular Formula:C₃₃H₄₆O₅Si
Molecular Weight:550.811
Hs Code.:

Synonyms:((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

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Chemical Property of ((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

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Technology Process of ((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

There total 6 articles about ((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 3587-60-8
Benzyloxymethyl chloride

: 204202-31-3
(2S,3R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-2,4-dimethyl-pentan-1-ol

: 204202-32-4
((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: With iPrNH; a) RT, 18 h, b) reflux, 24 h;
DOI:10.1016/S0957-4166(97)00596-X

Reference yield:

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 204202-32-4
((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) dibutylboron triflate, diisopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 30 min

2: 78 percent / NaOMe / tetrahydrofuran

3: 95 percent / iPr₂NEt / 18 h / 38 °C

4: 92 percent / DIBAL / tetrahydrofuran; toluene / 0.25 h

5: 69 percent / iPrNH / a) RT, 18 h, b) reflux, 24 h

With di-n-butylboryl trifluoromethanesulfonate; sodium methylate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1016/S0957-4166(97)00596-X

Reference yield:

: 95514-04-8
(R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

: 204202-32-4
((2S,3R,4S)-5-Benzyloxymethoxy-3-methoxymethoxy-2,4-dimethyl-pentyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N

2: 1.) dibutylboron triflate, diisopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 30 min

3: 78 percent / NaOMe / tetrahydrofuran

4: 95 percent / iPr₂NEt / 18 h / 38 °C

5: 92 percent / DIBAL / tetrahydrofuran; toluene / 0.25 h

6: 69 percent / iPrNH / a) RT, 18 h, b) reflux, 24 h

With oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; sodium methylate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1016/S0957-4166(97)00596-X