Technology Process of methyl 3-bromo-2-methoxy-6-(piperidin-1-ylsulphonylmethyl)benzoate
There total 3 articles about methyl 3-bromo-2-methoxy-6-(piperidin-1-ylsulphonylmethyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-bromo-3-methoxy-2-methoxycarbonylphenyl)-methanesulphonic acid sodium;
With
thionyl chloride;
In
dichloromethane;
at 50 ℃;
for 2h;
piperidine;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3 h / illuminated with a 500W tungsten filament lamp
2.1: sodium sulfite / ethanol; water / 2 h / Reflux
3.1: thionyl chloride / dichloromethane / 2 h / 50 °C
3.2: 4 h / 20 °C
With
thionyl chloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium sulfite;
2,2'-azobis(isobutyronitrile);
In
ethanol; dichloromethane; water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium sulfite / ethanol; water / 2 h / Reflux
2.1: thionyl chloride / dichloromethane / 2 h / 50 °C
2.2: 4 h / 20 °C
With
thionyl chloride; sodium sulfite;
In
ethanol; dichloromethane; water;
