N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

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Chemical Name:N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide
CAS No.:1365261-73-9
Molecular Formula:C₂₄H₁₉F₁₂N₃O₂
Molecular Weight:609.415
Hs Code.:

N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

Synonyms:N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

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Chemical Property of N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

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Technology Process of N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

There total 8 articles about N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080631-18-0
N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

: 1365261-73-9
N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 3h;

Reference yield:

: 261635-79-4
methyl 6-chloro-4-(trifluoromethyl)pyridine-3-carboxylate

: 1365261-73-9
N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 24 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

3.2: 2 h / 0 - 20 °C

4.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 20 °C

5.1: hydrazine hydrate / ethanol / 5 h / 80 °C

6.1: dichloromethane / 20 °C

7.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / 0 °C

With ammonium cerium (IV) nitrate; oxalyl dichloride; hydrazine hydrate; water; potassium carbonate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1364674-28-1
methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

: 1365261-73-9
N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / ethanol / 24 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

2.2: 2 h / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 20 °C

4.1: hydrazine hydrate / ethanol / 5 h / 80 °C

5.1: dichloromethane / 20 °C

6.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / 0 °C

With ammonium cerium (IV) nitrate; oxalyl dichloride; hydrazine hydrate; water; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;