methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

Base Information

Chemical Name:methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate
CAS No.:1364674-28-1
Molecular Formula:C₂₁H₁₄F₁₂N₂O₂
Molecular Weight:554.335
Hs Code.:

Synonyms:methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

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Chemical Property of methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

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Technology Process of methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

There total 1 articles about methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261635-79-4
methyl 6-chloro-4-(trifluoromethyl)pyridine-3-carboxylate

: 1072916-29-0
3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidine

: 1364674-28-1
methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield:

: 1364674-28-1
methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

: 1221784-94-6
6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 24h;

Reference yield:

: 1364674-28-1
methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate

: 1365261-73-9
N-{[6-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / ethanol / 24 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

2.2: 2 h / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 20 °C

4.1: hydrazine hydrate / ethanol / 5 h / 80 °C

5.1: dichloromethane / 20 °C

6.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / 0 °C

With ammonium cerium (IV) nitrate; oxalyl dichloride; hydrazine hydrate; water; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;