2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

Base Information

Chemical Name:2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone
CAS No.:1044591-16-3
Molecular Formula:C₃₀H₄₀N₂O₅
Molecular Weight:508.658
Hs Code.:

Synonyms:2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

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Chemical Property of 2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

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Technology Process of 2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

There total 4 articles about 2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 75226-98-1
4-(1-Oxo-2',4'-dimethoxybenzyl)phenoxyacetic acid

: 16898-52-5
1,3-di(piperidin-4-yl)propane

: 1044591-16-3
2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2009.03.012 DOI:10.1002/ardp.200900021

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 1044591-16-3
2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) chloride; trichlorophosphate / 2 h / 60 - 70 °C

2: potassium carbonate / 10 h / Reflux

3: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; zinc(II) chloride; trichlorophosphate; In N,N-dimethyl-formamide; 1: Friedel Crafts acylation;
DOI:10.1111/j.1747-0285.2011.01307.x

Reference yield:

: 151-10-0
1,3-Dimethoxybenzene

: 1044591-16-3
2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) chloride; trichlorophosphate / 2 h / 60 - 70 °C

2: potassium carbonate / 10 h / Reflux

3: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; zinc(II) chloride; trichlorophosphate; In N,N-dimethyl-formamide; 1: Friedel Crafts acylation;
DOI:10.1111/j.1747-0285.2011.01307.x