1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

Base Information

Chemical Name:1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one
CAS No.:1333331-63-7
Molecular Formula:C₂₅H₂₁FN₂O₄
Molecular Weight:432.451
Hs Code.:

Synonyms:1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

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Chemical Property of 1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

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Technology Process of 1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

There total 7 articles about 1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351410-62-3
5-fluoro-2-methoxypyridine-3-carbaldehyde

: 1333331-95-5
1-biphenyl-3-yl-5-[(4-methoxybenzyl)oxy]-2-methylpyridin-4(1H)-one

: 1333331-63-7
1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

Guidance literature:: 1-biphenyl-3-yl-5-[(4-methoxybenzyl)oxy]-2-methylpyridin-4(1H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.00833333h;

5‐fluoro‐2‐methoxypyridine‐3‐carbaldehyde; In tetrahydrofuran;

With trifluoroacetic acid; In Dichlorodifluoromethane;

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1333331-63-7
1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / water; methanol / 4.5 h / Reflux

2: thionyl chloride / diethyl ether / 1 h / 18 - 25 °C

3: zinc; ammonium chloride / water / 2 h / 18 - 70 °C

4: acetic acid / water / 18 h / 160 °C

5: hydrogenchloride; water / 18 h / 140 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 18 - 25 °C

7: lithium hexamethyldisilazane / tetrahydrofuran / 0.01 h

With hydrogenchloride; thionyl chloride; water; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 100397-13-5
5-(benzyloxy)-2-methyl-4H-pyran-4-one

: 1333331-63-7
1-biphenyl-3-yl-2-[2-(5-fluoro-2-methoxypyridin-3-yl)-2-hydroxyethyl]-5-hydroxypyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / water / 18 h / 160 °C

2: hydrogenchloride; water / 18 h / 140 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 18 - 25 °C

4: lithium hexamethyldisilazane / tetrahydrofuran / 0.01 h

With hydrogenchloride; water; potassium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide;