Technology Process of 4,4'-((2,5-bis((triisopropylsilyl)ethynyl)-1,4-phenylene)bisoxy)dibutanoic acid
There total 7 articles about 4,4'-((2,5-bis((triisopropylsilyl)ethynyl)-1,4-phenylene)bisoxy)dibutanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dimethyl 4,4'-((2,5-bis((triisopropylsilyl)ethynyl)-1,4-phenylene)bisoxy)dibutanoate;
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 16h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
pH=2;
DOI:10.1021/ma200296t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 120 °C / Inert atmosphere
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 40 h / 60 °C
3.1: trifluoroacetic acid / dichloromethane / 0.5 h
4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h
5.1: sodium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C
5.2: pH 2
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2.1: Sonogashira coupling;
DOI:10.1021/ma200296t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 72 h / 60 °C
2.1: sodium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C
2.2: pH 2
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1.1: Sonogashira coupling;
DOI:10.1021/ma200296t
