(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Base Information

Chemical Name:(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate
CAS No.:159622-47-6
Molecular Formula:C₂₈H₃₉N₃O₉
Molecular Weight:561.632
Hs Code.:

(2S,3R) benzyl 2-<N,N'-bis(tert-butoxycarbonyl)hydrazino>-3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Synonyms:(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Chemical Property:

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Technology Process of (2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

There total 7 articles about (2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1877-75-4
2-(4-methoxyphenoxy)acetic acid

: 159622-47-6
(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine, N,N'-carboxyldiimidazole, 4-dimethylaminopyridine / CH₂Cl₂ / 0 deg C, 1 h; room temp., 5 h

2: toluene / 0.75 h / 85 °C

3: 69 percent / ethanol; H₂O / 30 h / baker's yeast, immobilized on calcium alignate, fermented at 29 deg C, wit sucrose

4: 48 percent / 1.) lithium di-iso-propylamide / tetrahydrofuran; hexane / 1.) -40 deg C, 5 min -> 0 deg C, 30 min; 2.) -20 deg C -> 0 deg C

5: hydrogen / 10percent Pd/C / ethanol / 2 h

6: N-ethyl-N'-(3-dimethylaminopropyl)carboidimide / H₂O; tetrahydrofuran / 1 h

With pyridine; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)89309-1

Reference yield:

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 159622-47-6
(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / 1.) lithium di-iso-propylamide / tetrahydrofuran; hexane / 1.) -40 deg C, 5 min -> 0 deg C, 30 min; 2.) -20 deg C -> 0 deg C

2: hydrogen / 10percent Pd/C / ethanol / 2 h

3: N-ethyl-N'-(3-dimethylaminopropyl)carboidimide / H₂O; tetrahydrofuran / 1 h

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water;
DOI:10.1016/S0040-4020(01)89309-1

Reference yield:

: 646034-68-6
4-(4-Methoxy-phenoxy)-3-oxo-butyric acid

: 159622-47-6
(2S,3R) benzyl 2--3-hydroxy-4-(4-methoxyphenoxy)-butanohydroxamate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 0.75 h / 85 °C

2: 69 percent / ethanol; H₂O / 30 h / baker's yeast, immobilized on calcium alignate, fermented at 29 deg C, wit sucrose

3: 48 percent / 1.) lithium di-iso-propylamide / tetrahydrofuran; hexane / 1.) -40 deg C, 5 min -> 0 deg C, 30 min; 2.) -20 deg C -> 0 deg C

4: hydrogen / 10percent Pd/C / ethanol / 2 h

5: N-ethyl-N'-(3-dimethylaminopropyl)carboidimide / H₂O; tetrahydrofuran / 1 h

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water; toluene;
DOI:10.1016/S0040-4020(01)89309-1