1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione

Base Information

• Chemical Name: 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione
• CAS No.: 1334103-18-2
• Molecular Formula: C₁₄H₈F₃N₃O₃
• Molecular Weight: 323.231

Synonyms:1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione

Chemical Property of 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione

There total 4 articles about 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione (1334103-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 9 h / 20 °C / Reflux

2: ammonium chloride; zinc / ethanol / 6 h / 20 °C / Reflux

3: hydrogenchloride / water / 15 h / Reflux

With hydrogenchloride; ammonium chloride; triethylamine; zinc; In ethanol; water; isopropyl alcohol;

DOI:10.1002/ardp.201100103

Reference yield:

3-nitro-N-(4-(trifluoromethoxy)phenyl)pyridin-2-amine (1333931-08-0) → 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione (1334103-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; zinc / ethanol / 6 h / 20 °C / Reflux

2: hydrogenchloride / water / 15 h / Reflux

With hydrogenchloride; ammonium chloride; zinc; In ethanol; water;

DOI:10.1002/ardp.201100103

Reference yield:

4-(trifluoromethoxy)aniline (461-82-5) → 1,4-dihydro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazine-2,3-dione (1334103-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 9 h / 20 °C / Reflux

2: ammonium chloride; zinc / ethanol / 6 h / 20 °C / Reflux

3: hydrogenchloride / water / 15 h / Reflux

With hydrogenchloride; ammonium chloride; triethylamine; zinc; In ethanol; water; isopropyl alcohol;

DOI:10.1002/ardp.201100103

upstream raw materials:

2-Chloro-3-nitropyridine

3-nitro-N-(4-(trifluoromethoxy)phenyl)pyridin-2-amine

C₁₂H₁₀F₃N₃O

oxalic acid

Downstream raw materials:

2-hydrazinyl-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

2-chloro-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

2-(2-(3-allyl-5-tert-butyl-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

2-(2-(3-allyl-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

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