2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

Base Information

Chemical Name:2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene
CAS No.:334708-25-7
Molecular Formula:C₂₈H₃₀O₆S
Molecular Weight:494.609
Hs Code.:

Synonyms:2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

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Chemical Property of 2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

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Technology Process of 2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

There total 7 articles about 2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 334708-39-3
2-(3'-isopropoxy-4'-methoxyphenyl)-3-iodo-6-methoxybenzo[b]thiophene

: 334708-25-7
2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

Guidance literature:: 5-iodo-1,2,3-trimethoxybenzene; With tert.-butyl lithium; zinc(II) chloride; In tetrahydrofuran; at -78 - 20 ℃;

2-(3'-isopropoxy-4'-methoxyphenyl)-3-iodo-6-methoxybenzo[b]thiophene; With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/ol0067179

Reference yield:

: 153898-63-6
2-iodo-5-methoxyaniline

: 334708-25-7
2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / HBF₄; NaNO₂ / H₂O / 0.5 h / 0 - 20 °C

2.1: acetone / 1.75 h / 0 - 20 °C

3.1: KOH / methanol / 3 h

4.1: 59 percent / n-Bu₄NHSO₄ / CH₂Cl₂; H₂O / 1 h

5.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.33 h / -78 - 20 °C

5.2: 96 percent / ZnCl₂; Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 1 h / 20 °C

6.1: 97 percent / I₂ / CH₂Cl₂ / 1 h / 20 °C

7.1: t-BuLi; ZnCl₂ / tetrahydrofuran; various solvent(s) / -78 - 20 °C

7.2: 86 percent / Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 16 h / 20 °C

With potassium hydroxide; tetrafluoroboric acid; n-butyllithium; iodine; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/ol0067179

Reference yield:

: 874903-81-8
dithiocarbonic acid O-ethyl ester S-(2-iodo-5-methoxyphenyl)

: 334708-25-7
2-(3'-isopropoxy-4'-methoxyphenyl)-6-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzo[b]thiophene

Guidance literature:: Multi-step reaction with 5 steps

1.1: KOH / methanol / 3 h

2.1: 59 percent / n-Bu₄NHSO₄ / CH₂Cl₂; H₂O / 1 h

3.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.33 h / -78 - 20 °C

3.2: 96 percent / ZnCl₂; Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 1 h / 20 °C

4.1: 97 percent / I₂ / CH₂Cl₂ / 1 h / 20 °C

5.1: t-BuLi; ZnCl₂ / tetrahydrofuran; various solvent(s) / -78 - 20 °C

5.2: 86 percent / Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 16 h / 20 °C

With potassium hydroxide; n-butyllithium; iodine; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol0067179