Technology Process of 2-Hydroxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene
There total 17 articles about 2-Hydroxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at -78 ℃;
for 3h;
DOI:10.1039/b006623k
- Guidance literature:
-
Multi-step reaction with 7 steps
1: K2CO3 / acetone / 21 h / Heating
2: 15.0 g / acetone / 3 h / Heating
3: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C
4: 98 percent / CuI; Et3N / PdCl2(PPh3)2 / dimethylformamide / 1 h / 20 °C
5: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
6: 96 percent / CuI; i-Pr2NH / PdCl2(PPh3)2 / dimethylformamide / 1.5 h / 60 °C
7: 81 percent / DIBAL-H / toluene; CH2Cl2 / 3 h / -78 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; potassium carbonate; triethylamine; diisopropylamine; potassium iodide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
4: Sonogashira reaction;
DOI:10.1039/b006623k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 15.0 g / acetone / 3 h / Heating
2: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C
3: 98 percent / CuI; Et3N / PdCl2(PPh3)2 / dimethylformamide / 1 h / 20 °C
4: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
5: 96 percent / CuI; i-Pr2NH / PdCl2(PPh3)2 / dimethylformamide / 1.5 h / 60 °C
6: 81 percent / DIBAL-H / toluene; CH2Cl2 / 3 h / -78 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; diisopropylamine; potassium iodide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
3: Sonogashira reaction;
DOI:10.1039/b006623k
