Technology Process of 2-Acetoxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene
There total 15 articles about 2-Acetoxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 1.5h;
DOI:10.1039/b006623k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: K2CO3 / acetone / 21 h / Heating
2: 15.0 g / acetone / 3 h / Heating
3: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C
4: 98 percent / CuI; Et3N / PdCl2(PPh3)2 / dimethylformamide / 1 h / 20 °C
5: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
6: 96 percent / CuI; i-Pr2NH / PdCl2(PPh3)2 / dimethylformamide / 1.5 h / 60 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; diisopropylamine; potassium iodide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone;
4: Sonogashira reaction;
DOI:10.1039/b006623k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 15.0 g / acetone / 3 h / Heating
2: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C
3: 98 percent / CuI; Et3N / PdCl2(PPh3)2 / dimethylformamide / 1 h / 20 °C
4: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C
5: 96 percent / CuI; i-Pr2NH / PdCl2(PPh3)2 / dimethylformamide / 1.5 h / 60 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; potassium iodide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone;
3: Sonogashira reaction;
DOI:10.1039/b006623k
