2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione

Base Information

Chemical Name:2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS No.:164584-67-2
Molecular Formula:C₁₈H₁₈N₂O₄
Molecular Weight:326.352
Hs Code.:
European Community (EC) Number:605-370-2
DSSTox Substance ID:DTXSID301146288
Nikkaji Number:J656.626J
Mol file:164584-67-2.mol

Synonyms:CBDivE_001737;SCHEMBL22699960;DTXSID301146288;STK699898;AKOS000427845;CCG-103407;164584-67-2;EU-0000407;N-(2-Hydroxyethyl)-4-morpholino-1,8-naphthalenedicarbimide;2-(2-Hydroxyethyl)-6-(4-morpholinyl)-1H-benz[de]isoquinoline-1,3(2H)-dione;2-(2-Hydroxyethyl)-6-(4-morpholinyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;2-(2-hydroxyethyl)-6-(morpholin-4-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione

Suppliers and Price of 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione

Chemical Property:

Vapor Pressure:3.73E-15mmHg at 25°C
Boiling Point:598.1°C at 760 mmHg
Flash Point:315.5°C
Density:1.388g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:326.12665706
Heavy Atom Count:24
Complexity:505

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C2=C3C=CC=C4C3=C(C=C2)C(=O)N(C4=O)CCO

Technology Process of 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione

There total 3 articles about 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 110-91-8,99108-56-2
morpholine

: 52559-37-2
N-hydroxyethyl-4-bromine-1,8-naphthalimide

: 164584-67-2
2-(2-hydroxyethyl)-6-morpholino-1H-benzo[de]isoquinoline-1,3(2H)-dione

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 60 ℃; for 48h; Reagent/catalyst; Solvent; Temperature;
DOI:10.1016/j.dyepig.2014.05.006

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 164584-67-2
2-(2-hydroxyethyl)-6-morpholino-1H-benzo[de]isoquinoline-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.75 h / 100 °C / Microwave irradiation

2: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 48 h / 60 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; toluene; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.dyepig.2014.05.006