5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

Base Information

• Chemical Name: 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine
• CAS No.: 1171006-89-5
• Molecular Formula: C₄₁H₅₁N₃O₈Si
• Molecular Weight: 741.957

Synonyms:5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

Chemical Property of 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

Chemical Property:

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Technology Process of 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

There total 2 articles about 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5'-O-(tert-butyldimethylsilyl)-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-88-4) + levulinic acid (123-76-2) → 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-89-5)

Guidance literature:

levulinic acid; With dicyclohexyl-carbodiimide; In 1,4-dioxane; at 0 ℃; for 1h;

5'-O-(tert-butyldimethylsilyl)-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine; With pyridine; In 1,4-dioxane;

Reference yield: 86.0%

5'-O-(tert-butyldimethylsilyl)-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-88-4) + levulinic anhydride (40608-06-8) → 5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-89-5)

Guidance literature:

With pyridine; dmap;

DOI:10.1039/b924321f

Reference yield: 100.0%

5'-O-(tert-butyldimethylsilyl)-3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-89-5) → 3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-90-8)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 48h;

DOI:10.1039/b924321f

upstream raw materials:

5'-O-(tert-butyldimethylsilyl)-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

levulinic anhydride

levulinic acid

Downstream raw materials:

3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

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