(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

Base Information

Chemical Name:(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate
CAS No.:455263-22-6
Molecular Formula:C₂₆H₂₆Cl₂FN₃O₄
Molecular Weight:534.415
Hs Code.:

Synonyms:(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

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Chemical Property of (2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

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Technology Process of (2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

There total 4 articles about (2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 455262-36-9
ethyl (2S)-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

: 455263-22-6
(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

Guidance literature:: With Selectfluor; In tetrahydrofuran; at 70 ℃; for 48h;
DOI:10.1021/ol034701n

Reference yield:

: 2719-27-9
cyclohexanylcarbonyl chloride

: 455263-22-6
(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / triethylamine / diethyl ether; hexane / 24 h / Heating

2: 92 percent / hydrochloric acid / H₂O / 24 h / 20 °C

3: 95 percent / tetrahydrofuran / 24 h / 20 °C

4: 89 percent / Selectfluor^TM / tetrahydrofuran / 48 h / 70 °C

With hydrogenchloride; Selectfluor; triethylamine; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1021/ol034701n

Reference yield:

: 455264-97-8
1-keto-3-hydroxy-spiro[3.5]non-2-ene

: 455263-22-6
(2S)-ethyl 2-[(2-fluoro-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 24 h / 20 °C

2: 89 percent / Selectfluor^TM / tetrahydrofuran / 48 h / 70 °C

With Selectfluor; In tetrahydrofuran;
DOI:10.1021/ol034701n