3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

Base Information

Chemical Name:3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine
CAS No.:917480-71-8
Molecular Formula:C₂₃H₁₅F₃N₂O₂
Molecular Weight:408.38
Hs Code.:

Synonyms:3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

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Chemical Property of 3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

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Technology Process of 3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

There total 3 articles about 3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 917480-70-7
6-(4'-methoxybiphenyl-4-yl)-3-(4-methoxyphenyl)-4-trifluoromethylpyridazine

: 917480-71-8
3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

Guidance literature:: With pyridine hydrochloride; at 220 ℃; for 1h;
DOI:10.1002/jhet.5570430516

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 917480-71-8
3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / CsCO₃; K₂CO₃ / Pd(PPh₃)4 / H₂O; ethanol; toluene / 30 h / Heating

2: 87 percent / pyridine hydrochloride / 1 h / 220 °C

With pyridine hydrochloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; 1: Suzuki cross-coupling reaction;
DOI:10.1002/jhet.5570430516

Reference yield:

: 560132-53-8
6-(p-bromophenyl)-3-chloro-4-trifluoromethylpyridazine

: 917480-71-8
3-(4-hydroxyphenyl)-6-(4'-hydroxybiphenyl-4-yl)-4-trifluoromethylpyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / CsCO₃; K₂CO₃ / Pd(PPh₃)4 / H₂O; ethanol; toluene / 30 h / Heating

2: 87 percent / pyridine hydrochloride / 1 h / 220 °C

With pyridine hydrochloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; 1: Suzuki cross-coupling reaction;
DOI:10.1002/jhet.5570430516