Technology Process of <β-<3,4-(methylenedioxy)phenyl>cyclohex-2-enyl>acetic acid
There total 9 articles about <β-<3,4-(methylenedioxy)phenyl>cyclohex-2-enyl>acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / CeCl3*7H2O, NaBH4 / methanol / 0.75 h / 0 °C
2: 93 percent / pyridine / CH2Cl2 / 1 h / 0 °C
3: 1.) LDA, HMPA, 2.) t-butyldimethylsilyl chloride / 1.) hexane, THF, -78 deg C, 15 min, 2.) hexane, THF, from -78 deg C to reflux, 16 h
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; cerium(III) chloride; tert-butyldimethylsilyl chloride; lithium diisopropyl amide;
In
methanol; dichloromethane;
DOI:10.1016/0040-4020(95)01098-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / Br2 / acetic acid / 1 h
2: 1.) n-BuLi / 1.) Et2O, 0 deg C
3: NaBH4 / ethanol / -22 °C
4: pyridine / 10 h
5: 1.) LDA, HMPA, 2.) t-BuMe2SiCl, 3.) AcOH
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; bromine; tert-butyldimethylsilyl chloride; acetic acid; lithium diisopropyl amide;
In
ethanol; acetic acid;
DOI:10.1021/ja00401a039
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) Et2O, 0 deg C
2: NaBH4 / ethanol / -22 °C
3: pyridine / 10 h
4: 1.) LDA, HMPA, 2.) t-BuMe2SiCl, 3.) AcOH
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; tert-butyldimethylsilyl chloride; acetic acid; lithium diisopropyl amide;
In
ethanol;
DOI:10.1021/ja00401a039
