1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

Base Information

Chemical Name:1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol
CAS No.:1276681-48-1
Molecular Formula:C₂₂H₂₀F₄N₄O₂
Molecular Weight:448.42
Hs Code.:

Synonyms:1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

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Chemical Property of 1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

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Technology Process of 1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

There total 11 articles about 1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276680-64-8
3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester

: 1276681-48-1
1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 105250-16-6
(2-methylpyridin-4-yl)methanol

: 1276681-48-1
1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / acetonitrile / 3 h / 140 °C / Inert atmosphere; sealed tube

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4.1: water; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere; sealed tube

5.1: triethylamine / dichloromethane / 0.08 h / -10 °C

5.2: -10 °C

6.1: sodium azide / N,N-dimethyl-formamide / 0.17 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1.5 h / 20 °C

8.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C

With 1H-imidazole; copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; water; potassium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1276681-48-1
1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / N,N-dimethyl-formamide; methanol / 75 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 - 20 °C

2.2: 3 h / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / acetonitrile / 3 h / 140 °C / Inert atmosphere; sealed tube

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6.1: water; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere; sealed tube

7.1: triethylamine / dichloromethane / 0.08 h / -10 °C

7.2: -10 °C

8.1: sodium azide / N,N-dimethyl-formamide / 0.17 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1.5 h / 20 °C

10.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C

With 1H-imidazole; copper(l) iodide; lithium aluminium tetrahydride; sodium azide; tetrabutyl ammonium fluoride; water; potassium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;