105250-16-6

Basic information

• Product Name: 2-METHYL-4-HYDROXYMETHYLPYRIDINE
• Synonyms: 2-METHYL-4-HYDROXYMETHYLPYRIDINE;4-Pyridinemethanol,2-methyl-(9CI);(2-Methylpyridin-4-yl)methanol;4-(Hydroxymethyl)-2-methylpyridine;(2-Methylpyridin-4-yl)methanol, 4-(Hydroxymethyl)-2-picoline;(2-Methyl-4-pyridyl)methanol
• CAS NO: 105250-16-6
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• Product Categories: PYRIDINE
• Mol File: 105250-16-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 239.36 °C at 760 mmHg
• Flash Point: 98.562 °C
• Appearance: /
• Density: 1.092 g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.46±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-4-HYDROXYMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-HYDROXYMETHYLPYRIDINE(105250-16-6)
• EPA Substance Registry System: 2-METHYL-4-HYDROXYMETHYLPYRIDINE(105250-16-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 105250-16-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 483, 2002 DOI: 10.1055/s-2002-20960

InChI:InChI=1/C7H9NO/c1-6-4-7(5-9)2-3-8-6/h2-4,9H,5H2,1H3

Upstream product

• 63875-01-4 2-methyl-pyridine-4-carbaldehyde 
• 152815-18-4 (2-chloro-6-methyl-pyridin-4-yl)-methanol 
• 67-56-1 methanol 
• 116600-45-4 1,2-Dimethoxy-pyridinium-methylsulfat 
• 4021-11-8 2-methylisonicotinic acid 
• 22282-99-1 4-bromo-2-methylpyridine 
• 1254928-94-3 2-methyl-isonicotinic acid pentafluorophenyl ester 
• 16830-24-3 methyl 2-methylisonicotinate 
• 7732-18-5 water 
• 931-19-1 2-methylpyridine N-oxide 
• 108-47-4 2,4-lutidine 
• 55485-90-0 acetic acid 2-methyl-pyridin-4-ylmethyl ester 
• 1122-45-8 2,4-dimethylpyridine N-oxide 
• 108-24-7 acetic anhydride 

Downstream Products

• 75523-42-1 2-methyl-pyridin-4-ylmethyl chloride 
• 1276681-48-1 1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol 
• 1276680-67-1 3-(4-fluorophenyl)-7-hydroxymethylindolizine-2-carboxylic acid ethyl ester 
• 1276680-68-2 3-(4-fluorophenyl)-7-methanesulfonyloxymethylindolizine-2-carboxylic acid ethyl ester 
• 1276680-69-3 7-azidomethyl-3-(4-fluorophenyl)indolizine-2-carboxylic acid ethyl ester 
• 1276680-72-8 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide 
• 1276680-70-6 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide 
• 1276680-64-8 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester 
• 1276680-73-9 3-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-trifluoromethylpropyl)[1,3,4]oxadiazol-2-ylamino]methyl}indolizine-2-carboxylic acid ethyl ester 
• 1276680-74-0 3-(4-fluorophenyl)-7-formylindolizine-2-carboxylic acid ethyl ester 
• 1276680-76-2 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid 
• 1276680-77-3 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid methoxymethylamide 
• 1276680-78-4 1-{3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizin-2-yl}ethanone 

Relevant articles and documents

Regioselective hydroxylation of 2,4-lutidine: A practical synthesis of 4-hydroxymethyl-2-methylpyridine

A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans' regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.

QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE

The present disclosure relates to new compounds or pharmaceutically acceptable salts or stereoisomers thereof of formula I as inhibitors of receptor tyrosine kinases (RTK), in particular extracellular mutants of ErbB-receptors. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the treatment of cancer in mammals (e.g. humans).

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.