(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

Base Information

Chemical Name:(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide
CAS No.:170642-35-0
Molecular Formula:C₂₀H₂₆ClN₃O₄
Molecular Weight:407.897
Hs Code.:

Synonyms:(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

Suppliers and Price of (S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

Chemical Property:

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Technology Process of (S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

There total 9 articles about (S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

: 170642-34-9
2-chloro-3-<(methoxymethyl)oxy>-6-(iodomethyl)pyridine

: 170642-35-0
(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

: (S)-2-Amino-3-(6-chloro-5-methoxymethoxy-pyridin-2-yl)-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja9624073

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 170642-35-0
(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi, LiCl / hexane; tetrahydrofuran / 1 h / 0 °C

2: n-BuLi, diisopropylamine, LiCl / tetrahydrofuran; hexane / 5 h / -78 °C

With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja9624073

Reference yield:

: 185508-77-4
{[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-carbamic acid tert-butyl ester

: 170642-35-0
(S,S)-pseudoephedrine D-β-<6-chloro-5-<(methoxymethyl)oxy>-2-pyridyl>alaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / HCl / methanol / 3 h / 0 °C / other solvent, reagent

2: n-BuLi, diisopropylamine, LiCl / tetrahydrofuran; hexane / 5 h / -78 °C

With hydrogenchloride; n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ja9624073