Technology Process of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-tyrosine α-methyl ester
There total 1 articles about tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-tyrosine α-methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
1) -10 to -5 deg C, 2 h; 2) r.t., overnight;
- Guidance literature:
-
With
pyridinium acetyl sulfate;
In
pyridine; N,N-dimethyl-formamide;
at 40 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 84 percent / pyridinium acetyl sulfate / dimethylformamide; pyridine / 20 h / 40 °C
2: 42 percent / ethylenediaminetetraacetic acid, dithiothreitol, papain, aq. NaOH / methanol / 0.33 h / 30 °C / pH 9.1
3: 34 percent / H2O, CF3CO2H, thioglycolic acid, dithiothreitol / 3 h / 0 °C
With
sodium hydroxide; ethylenediaminetetraacetic acid; water; mercaptoacetic acid; pyridinium acetyl sulfate; trifluoroacetic acid; papain; diothiothreitol;
In
pyridine; methanol; N,N-dimethyl-formamide;
