4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

Base Information

Chemical Name:4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester
CAS No.:911029-65-7
Molecular Formula:C₁₇H₂₀BrN₃O₃S₃
Molecular Weight:490.466
Hs Code.:

Synonyms:4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

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Chemical Property of 4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

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Technology Process of 4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

There total 18 articles about 4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carboxamidine

: 24424-99-5
di-tert-butyl dicarbonate

: 911029-65-7
4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Product distribution / selectivity;

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 911029-65-7
4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: sulfuric acid / 0 °C

1.2: 2.5 h / 4 °C

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 1.5 h / 80 °C / Heating / reflux

3.1: acetic anhydride / 2 h / 17 - 130 °C / Heating / reflux

4.1: triethylamine / tetrahydrofuran / 1.75 h / 16.9 - 22.3 °C

5.1: iron; acetic acid / ethanol / 50 °C / Heating / reflux

6.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 50 - 80 °C

7.1: dihydrogen peroxide / water; acetic acid / 2 h / 50 °C

8.1: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 20 °C

9.1: tetrahydrofuran; ethanol / 2 h / -78 °C

10.1: sulfuric acid / 24 h / 20 °C

11.1: trimethylaluminum; ammonium chloride / toluene / 2.17 h / 80 °C

12.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; tert.-butylnitrite; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; trimethylaluminum; acetic anhydride; iron; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 41498-07-1
4-bromo-5-nitrothiophene-2-carbaldehyde

: 911029-65-7
4-[S-(3-bromophenyl)-sulfoximino]-5-methylsulfanyl-thiophene-2-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 1.5 h / 80 °C / Heating / reflux

2: acetic anhydride / 2 h / 17 - 130 °C / Heating / reflux

3: triethylamine / tetrahydrofuran / 1.75 h / 16.9 - 22.3 °C

4: iron; acetic acid / ethanol / 50 °C / Heating / reflux

5: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 50 - 80 °C

6: dihydrogen peroxide / water; acetic acid / 2 h / 50 °C

7: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 20 °C

8: tetrahydrofuran; ethanol / 2 h / -78 °C

9: sulfuric acid / 24 h / 20 °C

10: trimethylaluminum; ammonium chloride / toluene / 2.17 h / 80 °C

11: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; tert.-butylnitrite; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; trimethylaluminum; acetic anhydride; iron; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;