5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

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Chemical Name:5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione
CAS No.:1306740-85-1
Molecular Formula:C₅₃H₆₉N₉O₇
Molecular Weight:944.187
Hs Code.:

Synonyms:5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

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Chemical Property of 5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

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Technology Process of 5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

There total 6 articles about 5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 67-52-7,944357-77-1
BARBITURIC ACID

: 1306740-93-1
1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one

: 1306740-85-1
5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

Guidance literature:: With acetic acid; In acetic anhydride; at 90 ℃; for 3h;
DOI:10.1021/ma2004184

Reference yield:

: 905267-70-1
1-(3,5-dicarbethoxy)phenyl-2,6-dimethyl-4-pyridone

: 1306740-85-1
5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butyl lithium / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 25 °C / Inert atmosphere

3: acetic acid / acetic anhydride / 3 h / 90 °C

With tert.-butyl lithium; acetic acid; triethylamine; In tetrahydrofuran; acetic anhydride; 3: Knoevenagel condensation;
DOI:10.1021/ma2004184

Reference yield:

: 1-(3,5-dicarboxy)phenyl-2,6-dimethyl-4-pyridone hydrochloride

: 1306740-85-1
5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / toluene / 6 h / 110 °C

2: tert.-butyl lithium / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 25 °C / Inert atmosphere

4: acetic acid / acetic anhydride / 3 h / 90 °C

With sulfuric acid; tert.-butyl lithium; acetic acid; triethylamine; In tetrahydrofuran; acetic anhydride; toluene; 4: Knoevenagel condensation;
DOI:10.1021/ma2004184