1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one

Base Information

• Chemical Name: 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one
• CAS No.: 1306740-93-1
• Molecular Formula: C₄₉H₆₇N₇O₅
• Molecular Weight: 834.115
• Mol file: 1306740-93-1.mol

Synonyms:1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one

Chemical Property of 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one

There total 6 articles about 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-[3,5-bis(6-aminopyridin-2-yl)carbamoyl]phenyl-2,6-dimethyl-4-pyridone (905267-71-2) + n-dodecanoyl chloride (112-16-3) → 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one (1306740-93-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1021/ma2004184

Reference yield:

1-(3,5-dicarbethoxy)phenyl-2,6-dimethyl-4-pyridone (905267-70-1) → 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one (1306740-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butyl lithium / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 25 °C / Inert atmosphere

With tert.-butyl lithium; triethylamine; In tetrahydrofuran;

DOI:10.1021/ma2004184

Reference yield:

1-(3,5-dicarboxy)phenyl-2,6-dimethyl-4-pyridone hydrochloride → 1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-one (1306740-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / toluene / 6 h / 110 °C

2: tert.-butyl lithium / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 25 °C / Inert atmosphere

With sulfuric acid; tert.-butyl lithium; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/ma2004184

upstream raw materials:

1-(3,5-dicarbethoxy)phenyl-2,6-dimethyl-4-pyridone

1-[3,5-bis(6-aminopyridin-2-yl)carbamoyl]phenyl-2,6-dimethyl-4-pyridone

n-dodecanoyl chloride

2.6-diaminopyridine

Downstream raw materials:

5-{1-[3,5-bis[6-(dodecanoylamino)pyridine-2-yl]carbamoylphenyl]-2,6-dimethyl-1H-pyridine-4-ylidene}pyrimidine-2,4,6-trione