5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 1350653-24-5
• Molecular Formula: C₁₃H₈F₂IN₃
• Molecular Weight: 371.128
• Mol file: 1350653-24-5.mol

Synonyms:5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Chemical Property of 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

• Boiling Point: 454.1±45.0 °C(Predicted)
• Density: 1.85±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

There total 6 articles about 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

o-fluorobenzyl bromide (446-48-0) + 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine (1350653-23-4) → 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1350653-24-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2,6-dichloro-5-fluoropyridine-3-carboxamide (113237-20-0) → 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1350653-24-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: zinc; acetic acid / methanol / 24 h / Reflux

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

3.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

4.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0 °C

4.2: 0.5 h / -10 °C

4.3: 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With boron trifluoride diethyl etherate; caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc; In tetrahydrofuran; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (82671-02-1) → 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (1350653-24-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / 1 h / 60 - 65 °C

1.2: 20 °C / Cooling

2.1: zinc; acetic acid / methanol / 24 h / Reflux

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

4.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

5.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0 °C

5.2: 0.5 h / -10 °C

5.3: 0 - 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With sulfuric acid; boron trifluoride diethyl etherate; caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc; In tetrahydrofuran; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;

upstream raw materials:

o-fluorobenzyl bromide

5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine

2,6-dichloro-5-fluoropyridine-3-carboxamide

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

Downstream raw materials:

5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidine-4,6-diamine

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine