4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

Base Information

Chemical Name:4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid
CAS No.:1467057-66-4
Molecular Formula:C₁₈H₁₃F₂NO₄
Molecular Weight:345.302
Hs Code.:

Synonyms:4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

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Chemical Property of 4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

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Technology Process of 4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

There total 10 articles about 4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1467060-39-4
4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carbaldehyde

: 1467057-66-4
4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; acetonitrile; tert-butyl alcohol; at 0 - 20 ℃; for 5h;

Reference yield:

: 203302-95-8
4-bromo-3,5-difluorophenylamine

: 1467057-66-4
4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; N-iodo-succinimide / 2 h / 20 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 2.17 h / 20 °C

2.2: 88 h / 20 - 50 °C

3.1: copper(l) iodide / N,N-dimethyl-formamide / 3.75 h / 110 °C / Sealed tube

4.1: N-(chloromethylidene) N-methylmethanaminium; sodium hydroxide / water / 1 h / 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

6.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; acetonitrile; tert-butyl alcohol / 5 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; N-iodo-succinimide; copper(l) iodide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N-(chloromethylidene) N-methylmethanaminium; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1467060-36-1
4-bromo-3,5-difluoro-2-iodoaniline

: 1467057-66-4
4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 2.17 h / 20 °C

1.2: 88 h / 20 - 50 °C

2.1: copper(l) iodide / N,N-dimethyl-formamide / 3.75 h / 110 °C / Sealed tube

3.1: N-(chloromethylidene) N-methylmethanaminium; sodium hydroxide / water / 1 h / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

5.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; acetonitrile; tert-butyl alcohol / 5 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; copper(l) iodide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N-(chloromethylidene) N-methylmethanaminium; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;