203302-95-8

Usage

Uses

Used in Organic Synthesis:
4-Bromo-3,5-difluoroaniline is used as a reactant in the field of organic synthesis for the creation of a wide range of chemical compounds. Its unique structure allows for versatile reactions, making it a valuable building block in the synthesis of various organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Bromo-3,5-difluoroaniline is used as an intermediate in the development of new drugs. Its specific functional groups and reactivity enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
4-Bromo-3,5-difluoroaniline is also employed in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its use in research contributes to the advancement of chemical knowledge and the discovery of innovative chemical processes.
Used in Dye and Pigment Industry:
Additionally, 4-Bromo-3,5-difluoroaniline finds application in the dye and pigment industry, where it is used as a starting material for the synthesis of various dyes and pigments. Its unique color properties make it a valuable component in the production of specialized colorants.

Upstream product

• 372-39-4 3,5-difluoroaniline 
• 541539-64-4 N-(4-bromo-3,5-difluorophenyl)acetamide 

Downstream Products

• 702644-83-5 4-bromo-2-chloro-3,5-difluoroaniline 
• 1022091-49-1 6-bromo-5,7-difluoroquinoline 
• 1202698-01-8 N-[(4-bromo-3,5-difluorine)phenyl]acrylamide 
• 1185767-02-5 5,7-difluoroquinoline-6-carbaldehyde 
• 1261159-74-3 N-[(4-bromo-3,5-difluoro-phenyl)]maleimide 
• 1374891-90-3 (R)-4-[5-(4-bromo-3,5-difluoro-phenylcarbamoyl)pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1417658-25-3 C₁₃H₇BrClF₂NO₂ 
• 1431386-74-1 3,5-difluoro-4-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]phenylamine 
• 1431386-10-5 N-{3,5-difluoro-4-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]phenyl}(2,6-difluorophenyl)carboxamide 
• 1467060-36-1 4-bromo-3,5-difluoro-2-iodoaniline 
• 1467060-37-2 4-bromo-3,5-difluoro-2-[(trimethylsilyl)ethynyl]aniline 
• 1467060-39-4 4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carbaldehyde 
• 1467057-66-4 4,6-difluoro-5-[4-(3-hydroxyoxetan-3-yl)phenyl]-1H-indole-3-carboxylic acid 
• 1467060-43-0 4,6-difluoro-5-{4-[1-(hydroxymethyl)cyclopropyl]phenyl}-1H-indole-3-carbaldehyde 

Relevant academic research and scientific papers

ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

HETEROCYCLIC HYDRAZONE COMPOUNDS AND THEIR USES TO TREAT CANCER AND INFLAMMATION

The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

Synthesis of polyfluorinated 4-phenyl-3,4-dihydroquinolin-2-ones and quinolin-2-ones via superacidic activation of N-(polyfluorophenyl)cinnamamides

The cyclization reactions of a series of polyfluorocinnamanilides in triflic acid (CF3SO3H) yield 4-phenyl-3,4-dihydroquinolin-2-ones, which include a polyfluorinated benzene moiety as a part of the quinoline scaffold. These compounds undergo dehydrophenylation in the presence of AlCl3 to give the corresponding polyfluoroquinolin-2-ones which are converted into polyfluorinated 2-chloroquinolines on treatment with POCl3. A mechanism for the cyclization reaction presuming the intermediacy of a superelectrophilic O,C-diprotonated form of the starting material is suggested.

SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS

Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3-C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.