(E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone

Base Information

• Chemical Name: (E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone
• CAS No.: 76699-13-3
• Molecular Formula: C₂₄H₁₈ClNO₂
• Molecular Weight: 387.865

Synonyms:(E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone

Chemical Property of (E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone

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Technology Process of (E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone

There total 1 articles about (E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2?(4?methoxyphenyl)?1H?indole?3?carbaldehyde (76195-80-7) + para-chloroacetophenone (99-91-2) → (E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone (76699-13-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; Ambient temperature;

Reference yield: 70.0%

(E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone (76699-13-3) + (2,4-dinitro-phenyl)-hydrazine (119-26-6) → 3-[5-(4-Chloro-phenyl)-2-(2,4-dinitro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-2-(4-methoxy-phenyl)-1H-indole (71491-06-0)

Guidance literature:

In acetic acid; for 5h; Heating;

Reference yield: 68.0%

(E)-1-(4-Chloro-phenyl)-3-[2-(4-methoxy-phenyl)-1H-indol-3-yl]-propenone (76699-13-3) + 4-nitrophenylhydrazone (100-16-3) → 3-[5-(4-Chloro-phenyl)-2-(4-nitro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-2-(4-methoxy-phenyl)-1H-indole (71654-74-5)

Guidance literature:

In acetic acid; for 5h; Heating;

upstream raw materials:

2?(4?methoxyphenyl)?1H?indole?3?carbaldehyde

para-chloroacetophenone

Downstream raw materials:

3-[5-(4-Chloro-phenyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl]-2-(4-methoxy-phenyl)-1H-indole

3-[5-(4-Chloro-phenyl)-2-(4-nitro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-2-(4-methoxy-phenyl)-1H-indole

3-[5-(4-Chloro-phenyl)-2-(2,4-dinitro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-2-(4-methoxy-phenyl)-1H-indole

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