2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide
CAS No.:1443114-16-6
Molecular Formula:C₂₀H₁₆F₂N₄OS
Molecular Weight:398.436
Hs Code.:

Synonyms:2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

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Technology Process of 2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

There total 2 articles about 2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1443114-15-5
N-(4-(1H-benzo[d]imidazol-2-yl)thiazol-2-yl)-2,6-difluorobenzamide

: 67-63-0,8013-70-5
isopropyl alcohol

: 1443114-16-6
2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

Guidance literature:: With diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml400166b

Reference yield:

: 7187-47-5
4-(1H-benzo[d]imidazol-2-yl)-1,3-thiazol-2-amine

: 1443114-16-6
2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: diethylazodicarboxylate / tetrahydrofuran; toluene / 12 h / 0 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/ml400166b