N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide

Base Information

• Chemical Name: N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide
• CAS No.: 220658-30-0
• Molecular Formula: C₃₆H₃₅NO₅
• Molecular Weight: 561.678

Synonyms:N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide

Chemical Property of N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide

There total 5 articles about N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Benzhydrylamine (91-00-9) + 2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxylic acid (220658-28-6) → N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide (220658-30-0)

Guidance literature:

With dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.3987/COM-98-8342

Reference yield:

2-Iodophenol (533-58-4) → N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide (220658-30-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / K₂CO₃ / acetone / 6 h / Heating

2: 85 percent / Na₂CO₃ / (Ph₃P)4Pd / dimethylformamide / 3 h / 90 °C

3: 1.) MeI, 2.) NaOH / 1.) DMF, 70 deg C, 1 d, 2.) DMF, water, 100 deg C, 12 h

4: 97 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; sodium carbonate; potassium carbonate; triethylamine; methyl iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.3987/COM-98-8342

Reference yield:

tert-butyl 4-bromobutyrate (110661-91-1) → N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide (220658-30-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / K₂CO₃ / acetone / 6 h / Heating

2: 85 percent / Na₂CO₃ / (Ph₃P)4Pd / dimethylformamide / 3 h / 90 °C

3: 1.) MeI, 2.) NaOH / 1.) DMF, 70 deg C, 1 d, 2.) DMF, water, 100 deg C, 12 h

4: 97 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; sodium carbonate; potassium carbonate; triethylamine; methyl iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.3987/COM-98-8342

upstream raw materials:

Benzhydrylamine

2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxylic acid

2-Iodophenol

tert-butyl 4-bromobutyrate

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