5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

Base Information

Chemical Name:5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one
CAS No.:1410839-88-1
Molecular Formula:C₂₄H₂₇BrO₃Si
Molecular Weight:471.466
Hs Code.:

Synonyms:5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

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Chemical Property of 5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

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Technology Process of 5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

There total 3 articles about 5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1410839-69-8
1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclohexa-2,5-dienecarboxylic acid

: 1410839-87-0
(1R,5S,6S)-5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

: 1410839-88-1
5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

Guidance literature:: With 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide; In hexane; chloroform; at -40 ℃; for 1h; Reagent/catalyst; enantioselective reaction;
DOI:10.1021/ol302908a

Reference yield:

: 62627-31-0
1-(hydroxymethyl)-2,5-cyclohexadiene-1-carboxylic acid

: 1410839-87-0
(1R,5S,6S)-5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

: 1410839-88-1
5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

2: (DHQD)2PHAL; N-Bromosuccinimide / hexane; chloroform / 1 h / -40 °C

With 1H-imidazole; N-Bromosuccinimide; (DHQD)2PHAL; In hexane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol302908a

Reference yield:

: C₁₃H₁₈O₄

: 1410839-87-0
(1R,5S,6S)-5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

: 1410839-88-1
5-bromo-1-(((tert-butyldiphenylsilyl)oxy)methyl)-7-oxabicyclo[4.2.0]oct-2-en-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

3: (DHQD)2PHAL; N-Bromosuccinimide / hexane; chloroform / 1 h / -40 °C

With 1H-imidazole; N-Bromosuccinimide; (DHQD)2PHAL; sodium hydroxide; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol302908a