N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

Base Information

Chemical Name:N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
CAS No.:1602577-55-8
Molecular Formula:C₁₄H₁₂BrN₅O₃S
Molecular Weight:410.251
Hs Code.:

Synonyms:N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

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Chemical Property of N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

Chemical Property:

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Technology Process of N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

There total 4 articles about N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 87253-62-1
5,7-dimethyl-1,2,4-triazolo<1,5-a>pyrimidine-2-carboxylic acid

: 1602577-55-8
N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.02.054

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1602577-55-8
N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / 72 h / Inert atmosphere; Reflux

2: hydrogenchloride; water / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.054

Reference yield:

: 114040-29-8
ethyl 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate

: 1602577-55-8
N-(2-bromophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.054