C₁₈H₁₀BrClFN₃O₃

Base Information

Chemical Name:C₁₈H₁₀BrClFN₃O₃
CAS No.:1089179-03-2
Molecular Formula:C₁₈H₁₀BrClFN₃O₃
Molecular Weight:450.651
Hs Code.:

C<sub>18</sub>H<sub>10</sub>BrClFN<sub>3</sub>O<sub>3</sub>

Synonyms:C₁₈H₁₀BrClFN₃O₃

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Chemical Property of C₁₈H₁₀BrClFN₃O₃

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Technology Process of C₁₈H₁₀BrClFN₃O₃

There total 9 articles about C₁₈H₁₀BrClFN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1089179-02-1
C₁₈H₁₀BrClFN₃O₂S

: 1089179-03-2
C₁₈H₁₀BrClFN₃O₃

Guidance literature:: With acetic acid; chloroacetic acid; In water; at 100 ℃; for 6h;

Reference yield:

: 473923-97-6
3-chloro-5-hydroxybenzonitrile

: 1089179-03-2
C₁₈H₁₀BrClFN₃O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / ISOPROPYLAMIDE / 0.5 h / 50 °C

1.2: 2 h / 125 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C

2.2: 2 h / -50 °C

2.3: -78 - 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

5.2: 1.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

6.3: 0.33 h / 160 °C / Microwave irradiation

7.1: potassium tert-butylate / diethyl ether / 18 h / 20 °C

7.2: 4 h / 80 °C

8.1: acetic acid; chloroacetic acid / water / 6 h / 100 °C

With sodium tetrahydroborate; potassium tert-butylate; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride; acetic acid; chloroacetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1007571-63-2
3-(6-bromo-2-fluoro-3-formyl-phenoxy)-5-chloro-benzonitrile

: 1089179-03-2
C₁₈H₁₀BrClFN₃O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

2.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

4.3: 0.33 h / 160 °C / Microwave irradiation

5.1: potassium tert-butylate / diethyl ether / 18 h / 20 °C

5.2: 4 h / 80 °C

6.1: acetic acid; chloroacetic acid / water / 6 h / 100 °C

With sodium tetrahydroborate; potassium tert-butylate; phosphorus tribromide; sodium hydride; acetic acid; chloroacetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;