3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one
CAS No.:1296870-00-2
Molecular Formula:C₁₈H₁₂Cl₂F₆N₂O₂
Molecular Weight:473.202
Hs Code.:

Synonyms:3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

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Chemical Property of 3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

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Technology Process of 3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

There total 6 articles about 3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1296870-13-7
tert-butyl {4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}carbamate

: 1296870-00-2
3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

Guidance literature:: tert-butyl {4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.41667h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 933451-84-4
2-(3,5-dichlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-ol

: 1296870-00-2
3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 60 °C

1.2: 20 °C

2.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

3.2: 4 h / 20 °C

4.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 2 h / 20 °C / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 1.42 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1296874-64-0
5-(3,5-dichlorophenyl)-5-(trifluoromethyl)oxazolidin-2-one

: 1296870-00-2
3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 2 h / 20 °C / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 1.42 h / 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydride; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;