N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

Base Information

Chemical Name:N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide
CAS No.:1296870-02-4
Molecular Formula:C₂₁H₁₆Cl₂F₆N₂O₃
Molecular Weight:529.266
Hs Code.:

Synonyms:N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

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Chemical Property of N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

Chemical Property:

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Technology Process of N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

There total 7 articles about N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1296870-00-2
3-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-2-one

: 123-62-6
propionic acid anhydride

: 1296870-02-4
N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 23h;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1296870-02-4
N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 2 h / 20 °C

1.2: Cooling with ice

2.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 60 °C

2.2: 20 °C

3.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

4.2: 4 h / 20 °C

5.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 2 h / 20 °C / Cooling with ice

6.1: trifluoroacetic acid / dichloromethane / 1.42 h / 20 °C

7.1: tetrahydrofuran / 23 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1296874-64-0
5-(3,5-dichlorophenyl)-5-(trifluoromethyl)oxazolidin-2-one

: 1296870-02-4
N-{4-[5-(3,5-dichlorophenyl)-2-oxo-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 2 h / 20 °C / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 1.42 h / 20 °C

4.1: tetrahydrofuran / 23 h / 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;