Naphthionic acid

Base Information

• Chemical Name: Naphthionic acid
• CAS No.: 84-86-6
• Molecular Formula: C10H9NO3S
• Molecular Weight: 223.252
• Hs Code.: DERIVATION
• European Community (EC) Number: 201-567-9,283-232-7,291-651-1,275-349-7
• NSC Number: 4155
• UNII: 8ZIK65C5CD
• DSSTox Substance ID: DTXSID3058909
• Nikkaji Number: J4.902F
• Wikipedia: Naphthionic_acid
• Wikidata: Q6964882
• Metabolomics Workbench ID: 55806
• ChEMBL ID: CHEMBL444041
• Mol file: 84-86-6.mol

Synonyms:1-naphthylamine-4-sulfonic acid;4-amino-1-naphthalenesulfonic acid;4-aminonaphthalene-1-sulfonic acid;4-aminonaphthalenesulfonic acid;naphthionic acid;naphthionic acid, cobalt salt;naphthionic acid, copper (2+) salt (2:1);naphthionic acid, magnesium (2:1) salt;naphthionic acid, monosodium salt

Chemical Property of Naphthionic acid

Chemical Property:

• Appearance/Colour: Slightly greyish to beige powder and granule
• Melting Point: 300 °C
• Refractive Index: 1.713
• Boiling Point: 434oC
• PKA: pK1: 2.81 (25°C)
• PSA: 88.77000
• Density: 1.502 g/cm³
• LogP: 3.33070
• Storage Temp.: Store below +30°C.
• Solubility.: Sparingly soluble in dichloromethane. Soluble in aqueous base.
• Water Solubility.: 309.9mg/L(20 oC)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 223.03031432
• Heavy Atom Count: 15
• Complexity: 322

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-1-naphthalenesulfonic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45-25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB
• Canonical SMILES: C1=CC=C2C(=C1)C(=CC=C2S(=O)(=O)O)N
• Uses: Intermediate for azo dyes, e.g., Congo red. 4-Amino-1-naphthalenesulfonic acid has potent therapeutic applications. Its sodium salt has been used as non-toxic hemostatic. It is also a metabolite of azo dyes.

Technology Process of Naphthionic acid

There total 38 articles about Naphthionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-amino-naphthalene (134-32-7) → 4-amino-1-naphthalenesufonic acid (84-86-6)

Guidance literature:

With sulfuric acid; 1.) 180-200 deg C, 2.5 h, 2.) 240 deg C, irradiation, 30 min;

Reference yield: 80.0%

1-Nitronaphthalene (86-57-7) + sodium hydrogensulfite → 4-amino-1-naphthalenesufonic acid (84-86-6) + 4-Aminonaphthalene-1,3-disulfonic acid (14245-99-9)

Guidance literature:

With ammonia; In not given;

Reference yield:

1-Nitronaphthalene (86-57-7) + water (7732-18-5) → 4-amino-1-naphthalenesufonic acid (84-86-6) + 1-amino-naphthalene (134-32-7)

Guidance literature:

at 60 - 75 ℃;

upstream raw materials:

1-Nitronaphthalene

1-naphthylnitrosobenzene

1-acetamidonaphthalene

1-bromo-4-naphthalenesulfonic acid

Downstream raw materials:

1-aminonaphthalene-2-sulfonic acid

4-(toluene-4-sulfonylamino)-naphthalene-1-sulfonic acid

4-nitrobenzenediazonium chloride

1-hydroxymethyl-4-methoxy-naphthalene

Refernces

• 1、 Brykov,Tselinskii,Astrat'ev. "Sulfonation of aromatic amines under conditions of microwave heating". . p. 493 - 495. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of aminoaryl-sulphonic acids". . . Retrieved 2008/06/13.